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KMID : 0370220210650060424
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Yakhak Hoeji
2021 Volume.65 No. 6 p.424 ~ p.431
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Effects of Several Drugs for Metabolic Syndrome on Phorbol Ester- or Epidermal Growth Factor-induced Gene Expression and Production of Airway MUC5AC Mucin: Investigation of Potential Regulator for Hypersecretion of Airway Mucus using Drug Repositioning Strategy
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Lee Hyun-Jae
Lee Choong-Jae
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Abstract
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We investigated whether rosiglitazone, metformin, thioctic acid, simvastatin, or glimepiride affects airwayMUC5AC mucin gene transcription or protein expression induced by phorbol 12-myristate 13-acetate (PMA) or epidermalgrowth factor (EGF) in NCI-H292 cells. Cells were pretreated with each agent for 30 min, then stimulated with PMA orEGF for 24 h. Of the five agents, rosiglitazone inhibited PMA-induced gene transcription and production of MUC5ACmucin in NCI-H292 cells. This result suggests that rosiglitazone, an antidiabetic peroxisome proliferator-activated receptorgamma (PPAR-γ) agonist, can inhibit PMA-induced mucin expression at mRNA and protein levels, through directly actingon airway epithelial cells.
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KEYWORD
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Airway mucin, Rosiglitazone, Metformin, Thioctic acid, Simvastatin, Glimepiride
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